RNA interference (RNAi) refers to a gene silencing phenomenon after the sequence-specific transcription induced by double-stranded RNA which is complementary to the gene of interest mRNA. The technological group built by centering on RNAi is called siRNA technology. Diseases caused by specific gene overexpression can be treated by the siRNA technology. The key for the technology to come into play is to efficiently deliver the artificially synthesized siRNA to target cells by carriers.
Our team mainly works on design, optimization and production, focuses on finding multiple carriers for efficient delivery of siRNA and finally utilize the siRNA technology for disease treatment.
As a cellular membrane structure, extracellular vesicles are considered as an ideal drug delivery carrier because they are low in immunogenicity, high in tolerance, biodegradable and nontoxic. Compared to the existing synthesis delivery systems, they have multiple advantages.
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